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GAB1
Anti-GAB1 Recombinant Antibody Products
- Rabbit Anti-GAB1 Recombinant Antibody (clone JU47-19) (MRO-0615-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Mouse Anti-GAB1 Recombinant Antibody (clone 1A7) (VS3-XY752)
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- Species Reactivity: Human
- Type: Mouse IgG1
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Microglial cells, Excitatory neurons)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enhanced (REH)
Interaction
Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1 (By similarity). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Within the complex interacts with METTL13 (PubMed:29408807). Interacts with GRB2 and with other SH2-containing proteins (PubMed:15010462). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with PTPRJ (PubMed:12475979). Interacts (phosphorylated) with PTPN11 (PubMed:15010462). Interacts with HCK (PubMed:15010462).
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Related Diseases
Gastric Cancer