Anti-GOT2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, a global provider of custom research antibodies and biochemicals for mitochondrial biology and metabolism research, offers the highest-quality anti-GOT2 recombinant antibodies. GOT2 is the mitochondrial isoform of aspartate aminotransferase, an integral component of the malate-aspartate shuttle, a system crucial for cellular energy metabolism. Our recombinant antibodies to GOT2 have been optimized and validated to be highly specific, enabling your research exploring mitochondrial function, amino acid biosynthesis, and energy metabolism in health and disease.

GOT2: A Key Mitochondrial Enzyme in the Malate-Aspartate Shuttle

Glutamic-Oxaloacetic Transaminase 2, or GOT2, is the mitochondrial form of the enzyme aspartate aminotransferase. It is involved in a variety of metabolic pathways, such as the malate-aspartate shuttle that moves reducing equivalents in the form of NADH from the cytosol into the mitochondrial matrix for oxidative phosphorylation. GOT2 is also involved in mitochondrial amino acid biosynthesis and gluconeogenesis. This mitochondrial enzyme is critical for maintaining cellular energetic homeostasis, and has also been implicated in metabolic disorders and cancer.

Alternative Names

Glutamic-Oxaloacetic Transaminase 2; Kynurenine Aminotransferase IV; Plasma Membrane-Associated Fatty Acid-Binding Protein; Glutamic-Oxaloacetic Transaminase 2, Mitochondrial; Kynurenine--Oxoglutarate Transaminase IV; Kynurenine--Oxoglutarate Transaminase 4; Glutamate Oxaloacetate Transaminase 2; Kynurenine Aminotransferase 4; Aspartate Aminotransferase 2; Fatty Acid-Binding Protein; Aspartate Transaminase 2; Transaminase A; EC 2.6.1.1; GOT2; Aspartate aminotransferase; mitochondrial; mAspAT; Fatty acidbinding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynu

Background

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene.

Anti-GOT2 rAb Products

The recombinant antibodies in our anti-GOT2 kit have been optimized to be highly specific, and were validated to specifically detect the mitochondrial form of the enzyme, with no cross-reactivity to the cytosolic aspartate aminotransferase isoform GOT1. This high specificity is critical for experiments that are designed to specifically explore mitochondrial metabolism. The rAbs are optimized for IHC and western blotting of mitochondrial fractions, and we have validated these modalities for robust and reproducible performance.

Table 1. Featured anti-GOT2 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to offering tools with the highest quality to the scientific community. The recombinant antibodies in our anti-GOT2 kit were produced using rigorous quality control (QC) protocols, and have been extensively validated to be pure, isoform-specific, and performing as expected in a validated application. This QC testing ensures that the final product we provide to you can be used in your laboratory to generate reproducible science with the best chance of making a high impact in the field.

Customer Reviews

rAb Production

Creative Biolabs' recombinant antibody production platform was built with the ever-evolving science community in mind. With the growth of research in the mitochondrial biology space, we provide reagents with state-of-the-art production technologies. Our anti-GOT2 recombinant antibodies are expressed in systems that have been optimized to ensure the antibody recognizes the native form of the mitochondrial enzyme. This process helps to guarantee a highly specific and active antibody for your discovery research.

Featured Anti-GOT2 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-GOT2 recombinant antibody production.

Fig.4 Gram-scale anti-GOT2 recombinant antibody production.

rAb Modalities

Creative Biolabs is focused on empowering the scientific community by providing the highest quality antibody solutions and supporting research at every stage with customizable formats. Our recombinant antibodies to GOT2 are offered in multiple modalities that can be customized to suit your application and support your research on this essential mitochondrial metabolism process worldwide.

Fig.5 Full-length anti-GOT2 recombinant antibody production and modalities.

Creative Biolabs' highly specific recombinant antibodies are ideal for research into the role of GOT2 in cellular energetics. Explore this essential mitochondrial enzyme with the isoform-specific quality and reliability you need from an antibody reagent. Trust Creative Biolabs for tools that will form a solid foundation for your work in the metabolic medicine space. Contact our team today.