Disease related genes, FDA approved drug targets, Human disease related genes
Intracellular, Membrane (different isoforms)
Group enriched (Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons)
Not detected in immune cells
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, HAP1, SiHa, WM-115)
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2 (By similarity). Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway (By similarity).
Ion channel, Ligand-gated ion channel, Receptor
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For Research Use Only. Not For Clinical Use.