Anti-GRK2 Products

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For Research Use Only. Not For Clinical Use.

Whether you're working in cardiovascular research or signal transduction, Creative Biolabs' recombinant antibodies against G protein-coupled receptor kinase 2 (GRK2) will be among the most specific available for your needs. As the most well-known kinase responsible for beta-adrenergic receptor desensitization, GRK2 is a major regulator of cardiac function and an important target in heart failure. Our high-quality anti-GRK2 antibodies will be a critical reagent in your studies of GPCR signaling and for developing new therapeutics for cardiovascular disease.

GRK2: The Master Regulator of Beta-Adrenergic Receptor Desensitization

G protein-coupled receptor kinase 2, also known as beta-adrenergic receptor kinase 1 or βARK1, is a serine/threonine kinase which phosphorylates and desensitizes G protein-coupled receptors. Beta-adrenergic receptors in the heart are chronically stimulated during heart failure. This leads to an upregulation and over-activity of GRK2. GRK2 phosphorylates the activated beta-adrenergic receptors, which facilitates binding of β-arrestin and internalization of the receptor, effectively shutting down receptor signaling. This leads to a dampened heart response to adrenaline and contributes to a failure to maintain cardiac output. Inhibition of GRK2 is a highly desirable therapeutic target for the treatment of heart failure.

Alternative Names

BARK1; ADRBK1; BETA-ARK1; beta-adrenergic receptor kinase 1; adrenergic beta receptor kinase 1; beta-ARK-1

Background

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.

Anti-GRK2 rAb Products

Our recombinant antibodies against GRK2 are designed for maximum specificity and performance, and are validated to ensure that they will detect GRK2 protein specifically in cardiac and other tissues. Optimized for a variety of applications including Western Blot to determine expression levels and co-immunoprecipitation to pull down GRK2 and its interacting proteins with the receptors, our recombinant antibodies (rAbs) give you the assurance you need to perform top-notch cardiovascular research.

Table 1. Featured anti-GRK2 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is dedicated to scientific accuracy, and the production of our anti-GRK2 recombinant antibodies is no exception. A stringent quality control process is in place for every stage of production. Each lot of our recombinant antibodies is tested for purity and specificity, as well as consistent performance in our validated applications to ensure you receive a product of the highest quality for your research.

Customer Reviews

rAb Production

Creative Biolabs has invested in state-of-the-art recombinant antibody production platforms to support the specific needs of cutting-edge GPCR signaling research. Our recombinant antibodies against GRK2 are expressed in systems which have been optimized to ensure that our antibodies will recognize the native form of the kinase, so you can be sure that you're getting a specific and active tool for your most challenging experiments.

Featured Anti-GRK2 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-GRK2 recombinant antibody production.

Fig.4 Gram-scale anti-GRK2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific discovery. Our recombinant antibodies against GRK2 are available in a variety of customizable modalities to support a wide range of applications and requirements, giving researchers around the world the freedom to study this important kinase.

Fig.5 Full-length anti-GRK2 recombinant antibody production and modalities.

Creative Biolabs' recombinant antibodies against G protein-coupled receptor kinase 2 (GRK2) will be one of the most specific tools you can get for dissecting the molecular mechanisms of GPCR desensitization. We have the validation and consistency to give you confidence when studying this important therapeutic target in heart failure. Allow our expertise to be the foundation of your work and contact our scientific team today.