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GRK2
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (dendritic cells, Macrophages, Theca cells, Hofbauer cells, Adipocytes, Pancreatic endocrine cells, T-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (NB-4, REH)
Interaction
Interacts with the heterodimer formed by GNB1 and GNG2 (By similarity). Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5 (PubMed:10085131). Interacts with ARRB1 (PubMed:9501202). Interacts with LPAR1 and LPAR2 (PubMed:19306925). Interacts with RALA in response to LPAR1 activation (PubMed:19306925). ADRBK1 and RALA mutually inhibit each other's binding to LPAR1 (PubMed:19306925). Interacts with ADRB2 (PubMed:19715378).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Signaling Pathways
Hedgehog Signaling Pathway
- PE-B*07:02/Human GRK2 (KPRSPVVEL) MHC Tetramer (MHC-LC4419)
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- Class: Class I
- Antigen: GRK2
- Antigen Species: Human
- Peptide: KPRSPVVEL
- Conjugate: PE
- Rabbit Anti-GRK2 Recombinant Antibody (clone CBACN-250) (MRO-0694-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, FC, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
- Rabbit Anti-GRK2 Polyclonal Antibody (VS3-WK1568)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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For Research Use Only. Not For Clinical Use.