Rabbit Anti-GRK2 Polyclonal Antibody
CAT#: VS3-WK1568
This antibody is a rabbit polyclonal antibody against human GRK2, which can phosphorylate the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, cytoskeletal, mitochondrial, and transcription factor proteins. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human GRK2). It can detect endogenous levels of GRK2. This product was tested for use in WB and ELISA.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/60707/1779_F5_2_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_8_8.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (NB-4, REH)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000173020-GRK2
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Specifications
- Immunogen
- Synthesized peptide derived from human GRK2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GRK2
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).
Target
- Alternative Names
- G Protein-Coupled Receptor Kinase 2; EC 2.7.11.15; Beta-ARK-1; ADRBK1; BARK1; Adrenergic, Beta, Receptor Kinase 1; G-Protein Coupled Receptor Kinase 2
- Gene ID
- 156
- UniProt ID
- P25098
- Long Name
- G Protein-Coupled Receptor Kinase 2
- Sequence Similarities
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse
- Protein Refseq
- NP_001610.2
- Function
- Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.
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Related Signaling Pathways
Hedgehog Signaling Pathway
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "GRK2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0093 | Rabbit Anti-GRK2 Recombinant Antibody (clone DS93AB) | WB, IHC-P, ICC, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4419 | PE-B*07:02/Human GRK2 (KPRSPVVEL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0395J | Mouse Anti-GRK2 Recombinant Antibody (ZG-0395J) | WB, IHC, IF, ELISA | Mouse IgG |
| ZG-0396J | Mouse Anti-GRK2 Recombinant Antibody (ZG-0396J) | WB | Mouse IgG |
| VS3-QX478 | Mouse Anti-GRK2 Recombinant Antibody (clone 6C1-D9-C0) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-CJ817 | Rabbit Anti-GRK2 Recombinant Antibody (VS3-CJ817) | WB, IHC | Rabbit IgG |
| VS3-WK2189 | Rabbit Anti-GRK2 (pS685) Recombinant Antibody (VS3-WK2189) | WB, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY233 | Mouse Anti-NHP GRK2 Recombinant Antibody (clone 3F8) | WB, IHC, IF, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2927 | Anti-GRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2928 | Anti-Mouse GRK2 Immunohistochemistry Kit | IHC |
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