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    Rabbit Anti-GRK2 Polyclonal Antibody (CAT#: VS3-WK1568)

    This antibody is a rabbit polyclonal antibody against human GRK2, which can phosphorylate the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, cytoskeletal, mitochondrial, and transcription factor proteins. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human GRK2). It can detect endogenous levels of GRK2. This product was tested for use in WB and ELISA.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line REH
    Figure 1 IF staining of human cell line REH
    (Immunofluorescent staining of human cell line REH shows localization to cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/60707/1779_F5_2_selected.jpg
    Normal Tissue
    Figure 2 Lymph node
    Figure 2 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_8_8.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_9_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_9_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/37248/86033_A_5_6.jpg
    RNA Expression
    Figure 7 RNA cell line category: Cell line enhanced (NB-4, REH)
    Figure 7 RNA cell line category: Cell line enhanced (NB-4, REH)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000173020-GRK2

    Specifications

    • Immunogen
    • Synthesized peptide derived from human GRK2
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human GRK2
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • WB, ELISA
    • Conjugate
    • Unconjugated

    Product Property

    • Clonality
    • Polyclonal
    • Purification
    • Affinity purified
    • Purity
    • >95% as determined by SDS-PAGE
    • Aggregation
    • < 5%
    • Format
    • Liquid
    • Concentration
    • 1 mg/mL
    • Buffer
    • PBS, 0.5% BSA, 50% Glycerol
    • Preservative
    • 0.02% Sodium Azide
    • Storage
    • Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).

    Target

    • Alternative Names
    • G Protein-Coupled Receptor Kinase 2; EC 2.7.11.15; Beta-ARK-1; ADRBK1; BARK1; Adrenergic, Beta, Receptor Kinase 1; G-Protein Coupled Receptor Kinase 2
    • Long Name
    • G Protein-Coupled Receptor Kinase 2
    • Sequence Similarities
    • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    • Cellular Localization
    • Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse
    • Function
    • Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Related Resources

    • Related Signaling Pathways

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "GRK2"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Rabbit Monoclonal Antibody Products MHC Tetramer Products for Cancer IgG Antibody Products Non-Human Primate (NHP) Antibody Products
    CAT Product Name Application Type
    MOR-0093 Rabbit Anti-GRK2 Recombinant Antibody (clone DS93AB) WB, IHC-P, ICC, FC, IP Rabbit IgG

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