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HAND1
Loading...Anti-HAND1 Recombinant Antibody Products
- Mouse Anti-HAND1 Monoclonal Antibody (clone 8E7A11) (VS7-0425-WR12)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Mouse Anti-HAND1 Monoclonal Antibody (VS7-0425-WR13) (VS7-0425-WR13)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
Protein class
Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (SH-SY5Y, SuSa)
Interaction
Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC (By similarity). Interacts with SOX15; the interaction enhances HAND1-induced differentiation of trophoblast giant cells (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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