Anti-HAO1 Recombinant Antibody Products

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Anti-HAO1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in high-performance HAO1-targeting recombinant antibodies that accelerate discoveries in life science research. Utilizing state-of-the-art production platforms, we guarantee antibodies that exceed industry benchmarks for specificity and consistency. Researchers benefit from our comprehensive collection of meticulously engineered antibodies, each optimized for superior experimental outcomes. Beyond supplying premium-grade research reagents, our scientists provide personalized consultation to optimize your study design and implementation. Collaborating with us ensures access to groundbreaking antibody solutions backed by a passionate team invested in your research success.

HAO1: A Key Target in Oxalate Metabolism and Rare Kidney Disorders

HAO1 is a peroxisomal enzyme primarily involved in the oxidation of glycolate to glyoxylate, playing a key role in glyoxylate and oxalate metabolism. Dysregulation of HAO1 has been closely linked to primary hyperoxaluria type 1 (PH1), a rare genetic disorder characterized by the overproduction of oxalate, leading to kidney stones, nephrocalcinosis, and eventually renal failure. In PH1, inhibition of HAO1 has emerged as a promising therapeutic strategy to reduce hepatic oxalate production and prevent disease progression. Additionally, altered HAO1 expression or activity may have implications in other metabolic disorders related to peroxisomal dysfunction. Recent studies have also explored HAO1 as a target for RNA interference therapies, aiming to restore metabolic balance in affected individuals. Given its central role in oxalate synthesis and peroxisomal metabolism, HAO1 is gaining attention as both a biomarker and therapeutic target in metabolic kidney diseases and rare genetic conditions.

Alternative Names

Complement Hydroxyacid Oxidase 1; Hydroxyacid Oxidase (Glycolate Oxidase) 1; Glycolate Oxidase 1; HAOX1; GOX1; GOX; (S)-2-Hydroxy-Acid Oxidase; Glycolate Oxidase; EC 1.1.3.15

Background

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.

Anti-HAO1 rAb Products

At Creative Biolabs, we empower scientific breakthroughs through premium anti-HAO1 recombinant antibodies that combine exceptional specificity, cost-effectiveness, and comprehensive research support. Our rigorously validated antibodies enable reproducible results while our specialists provide tailored guidance to optimize your experimental workflows and maximize research outcomes.

Table 1. Featured anti-HAO1 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

O**er
Mouse Anti-HAO1 Antibody (clone Mix) (CAT#: ZG-0093C)

We used the Mouse Anti-HAO1 Antibody for immunofluorescence on HepG2 cells. The staining was specific and localized clearly to peroxisomal regions, with minimal background. It worked well with our standard IF protocol and didn't require much optimization. Overall, a dependable antibody for detecting HAO1 in cell-based imaging experiments.

09/Feb/2023

Excellent

So**e
Mouse Anti-HAO1 Recombinant Antibody (clone 22H7) (CAT#: MOB-3709z)

In our Western blot analysis using HEK293 cell lysates, the Mouse Anti-HAO1 Recombinant Antibody provided a clear, well-defined band at the expected molecular weight. Background signal was low, and the antibody required no special optimization. It delivered reproducible results and proved to be a dependable option for detecting HAO1 in our workflow.

19/Jun/2024

Excellent

F**ya
Rabbit Anti-HAO1 Recombinant Antibody (clone SI291DS) (CAT#: MOR-4212)

We tested the Rabbit Anti-HAO1 Recombinant Antibody in Western blot using lysates from HepG2 cells. The antibody produced a distinct band at the expected size with very low background. Signal intensity was strong and consistent across different experiments. It worked well with standard WB conditions and didn't require much troubleshooting. A reliable antibody for detecting HAO1 in liver-derived cell lines.

25/Oct/2024

rAb Production

Drawing upon decades of specialized expertise in engineered antibody production and optimization, we prioritize rapid delivery of rigorously validated research reagents without compromising quality standards. Our customer-focused approach combines responsive support with consistently reliable antibody formulations, ensuring researchers receive precisely tailored solutions within accelerated timelines.

Featured Anti-HAO1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

At Creative Biolabs, we empower scientists with an extensive portfolio of premium engineered antibodies in diverse configurations, developed through our mastery of cutting-edge antibody modification technologies. Our specialists excel in creating adaptable research solutions, with every antibody product complemented by fully customizable development services designed to address your project's specific biological challenges and experimental objectives.

Fig.3 Full Length Anti-HAO1 Recombinant Antibody Production and Modalities.

If you need more details about the HAO1 target, please don't hesitate to contact us by phone or email. Our experienced team is always ready to help with any questions or experimental challenges, ensuring you receive the support necessary for smooth and successful research.