HERC5
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Loading...- Mouse Anti-HERC5 Recombinant Antibody (HE1043) (VS-0326-YC1043)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IHC, IP, WB
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]