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HHLA2

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For Research Use Only. Not For Clinical Use.


This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Distal enterocytes, Proximal enterocytes, Paneth cells)

Immune cell specificity

Immune cell enhanced (myeloid DC)

Cell line specificity

Cell line enhanced (CACO-2, HDLM-2, Karpas-707)

Interaction

Interacts with TMIGD2.

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