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HIF1AN
Loading...Anti-HIF1AN Products
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IF, FC
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- Mouse Anti-HIF1AN Recombinant Antibody (VS3-WK1173) (VS3-WK1173)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IF, WB
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- Rabbit Anti-HIF1AN Recombinant Antibody (clone JG37-66) (MRO-0736-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Anti-Human HIF1AN Immunohistochemistry Kit (VS-0525-XY3140)
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- Species Reactivity: Human
- Target: HIF1AN
- Application: IHC
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- Anti-HIF1AN Immunohistochemistry Kit (VS-0325-XY1019)
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- Species Reactivity: Human, Mouse
- Target: HIF1AN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
HIF1AN (Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor) is a Protein Coding gene. Diseases associated with HIF1AN include Hypoxia and Anemia Of Prematurity. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and HIF-2-alpha transcription factor network. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is HSPBAP1.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4 (By similarity). Interacts with UBE3A. Interacts with ANKS3 (By similarity). Interacts with NECAB3; the interaction is indirect and seems to be mediated by APBA3.
Molecular function
Dioxygenase, Oxidoreductase
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