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Helicobacter pylori urease
Loading...Anti-Helicobacter pylori urease Products
- Anti-H. pylori urease Polyclonal Antibody (MRO-745-MZ)
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- Type: Duck antibody
- Application: WB, ELISA, Immunodiffusion, Immunoelectrophoresis
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For Research Use Only. Not For Clinical Use.
Background
Helicobacter pylori (Hp) is the most common pathogen in humans. It is a causative factor of gastritis and digestive ulcers, and is closely related to the occurrence of gastric cancer. There are many kinds of pathogenic processes in Hp. The involvement of pathogenic factors, Hp urease has been confirmed to be one of the few proteins closely related to Hp infection. High urease activity is one of the important biological properties of Hp, which can rapidly decompose urea into ammonia and Carbon dioxide has a unique role in the infection of Hp.
Hp urease is a common enzyme in gastrointestinal and urinary tract infection in humans and animals. It is not only one of the pathogenic factors of some pathogenic bacteria in humans and animals, but also one of the enzymes necessary for the transformation of some nitrogenous putrefactive substances. It is the first time that crystals have been obtained and metal enzymes containing Ni ions have been found.
The Hp urease monomer consists of two subunits, A and B, which are hexamers. The M of the two subunits A and B are about 30 000 and 64 000 respectively, and the ratio is 1:1.The urease contained is composed of three subunits. The amount of Hp urease is very large, accounting for 5% to 10% of the whole bacterial protein. Urease is generally a cytoplasmic protein, while Hp has a large amount of highly active extracellular urease, Hp. The urease activity produced is equivalent to 2 times that of Proteus mirabilis and 7 times that of urease-positive enterobacteria. Therefore, the determination of urease activity can be used as a rapid diagnostic method for Hp.
Hp urease is a common enzyme in gastrointestinal and urinary tract infection in humans and animals. It is not only one of the pathogenic factors of some pathogenic bacteria in humans and animals, but also one of the enzymes necessary for the transformation of some nitrogenous putrefactive substances. It is the first time that crystals have been obtained and metal enzymes containing Ni ions have been found.
The Hp urease monomer consists of two subunits, A and B, which are hexamers. The M of the two subunits A and B are about 30 000 and 64 000 respectively, and the ratio is 1:1.The urease contained is composed of three subunits. The amount of Hp urease is very large, accounting for 5% to 10% of the whole bacterial protein. Urease is generally a cytoplasmic protein, while Hp has a large amount of highly active extracellular urease, Hp. The urease activity produced is equivalent to 2 times that of Proteus mirabilis and 7 times that of urease-positive enterobacteria. Therefore, the determination of urease activity can be used as a rapid diagnostic method for Hp.
