Histone H2A
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For Research Use Only. Not For Clinical Use.
Background
Predicted to enable DNA binding activity. Involved in DNA repair. Part of replication fork protection complex. Orthologous to several human genes including H2AC21 (H2A clustered histone 21) and H2AJ (H2A.J histone).
Histone H2A is a fundamental core histone protein essential for packaging DNA into chromatin, forming part of the nucleosome core around which DNA wraps, and playing critical roles in regulating gene expression, DNA repair, and genome stability through various modifications and diverse variants like H2A.X, influencing fundamental biological processes and disease.