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IFNGR2
Anti-IFNGR2 Recombinant Antibody Products
- Hamster Anti-Ifngr2 Recombinant Antibody (clone 7A25) (NEUT-1044CQ)
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: Neut, WB
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- Hamster Anti-Ifngr2 Recombinant Antibody (clone MOB47) (NEUT-1045CQ)
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: WB, FC, CyTOF, Neut
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- Hamster Anti-Ifngr2 Recombinant Antibody (clone CBL072) (NEUT-1046CQ)
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: WB, Neut
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For Research Use Only. Not For Clinical Use.
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Urothelial cells, Prostatic glandular cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
Heterodimer with IFNGR1, to form the IFNG receptor complex (PubMed:7615558). Interacts (via intracellular domain) with JAK2 (PubMed:7615558, PubMed:7673114).
Molecular function
Receptor
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