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IL36RN
Loading...Anti-IL36RN Products
- Anti-Human IL36RN Recombinant Antibody (TAB-430CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Human Anti-IL36RN Antibody, mRNA (TAB-430CL-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.
Background
The IL36RN gene provides instructions for making the interleukin-36 receptor antagonist (IL-36Ra) protein, which helps to regulate inflammation, especially in the skin. Mutations or deficiencies in the IL36RN gene can lead to a lack of functional IL-36Ra, resulting in an overactive immune system and chronic inflammation.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts, Extravillous trophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (BEWO, GAMG, U-87 MG)
Interaction
Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
Molecular function
Cytokine
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