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IRAK3
Anti-IRAK3 Recombinant Antibody Products
- Rabbit Anti-IRAK3 Recombinant Antibody (VS3-WK1231) (VS3-WK1231)
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IF
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IP, WB
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- Anti-IRAK3 Immunohistochemistry Kit (VS-0325-XY1139)
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- Species Reactivity: Human, Mouse, Rat
- Target: IRAK3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Macrophages, Kupffer cells, Microglial cells, monocytes, Adipocytes)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, neutrophil, basophil, myeloid DC)
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, HEL, HL-60, NB-4, THP-1, U-937)
Interaction
Monomer (PubMed:33238146). Homodimer; disulfide-linked (PubMed:33238146). May interact with IRAK4 (when phosphorylated) (PubMed:33238146). Interacts (when phosphorylated at Ser-110) with PIN1 (via WW domain) in response to IL33-mediated (but not TLR4 ligand LPS) dendritic cell stimulation (PubMed:29686383).
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