ITGA4 and ITGB7
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, WB
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- Derivation: human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: IP, IF, FuncS, FC, Neut, ELISA
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For Research Use Only. Not For Clinical Use.
Background
ITGA4 (integrin subunit alpha 4) and ITGB7 (integrin subunit beta 7) together form the integrin α4β7. This integrin plays a crucial role in lymphocyte trafficking to the gut mucosa by mediating adhesion to MAdCAM-1 (mucosal addressin cell adhesion molecule-1) on endothelial cells. This interaction is essential for gut-associated immune responses.