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KDM5B
Anti-KDM5B Recombinant Antibody Products
- Recombinant Mouse Anti-Human KDM5B Antibody (MOB-1433MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-P, WB
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- Rabbit Anti-KDM5B Polyclonal Antibody (MRO-1992-CN) (MRO-1992-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4'; the interaction is inhibited when histone H3 is methylated at 'Arg-2' or 'Lys-4' (PubMed:24952722).
Molecular function
Chromatin regulator, Dioxygenase, Oxidoreductase, Repressor
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