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KDM5B
Loading...Anti-KDM5B Products
- Rabbit Anti-KDM5B Polyclonal Antibody (MRO-1992-CN) (MRO-1992-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA, FuncS
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- Recombinant Mouse Anti-Human KDM5B Antibody (MOB-1433MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF
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- Mouse Anti-KDM5B Recombinant Antibody (clone 7H3D7) (VS7-0425-WR203)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Anti-KDM5B Immunohistochemistry Kit (VS-0525-XY3756)
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- Species Reactivity: Human
- Target: KDM5B
- Application: IHC
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- Anti-Rat KDM5B Immunohistochemistry Kit (VS-0525-XY3757)
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- Species Reactivity: Human, Rat
- Target: KDM5B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9 or H3 Lys-27. Demethylates trimethylated, dimethylated and monomethylated H3 Lys-4. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4'; the interaction is inhibited when histone H3 is methylated at 'Arg-2' or 'Lys-4' (PubMed:24952722).
Molecular function
Chromatin regulator, Dioxygenase, Oxidoreductase, Repressor
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