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KLHL21

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For Research Use Only. Not For Clinical Use.


Background

Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Feb 2025]
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Squamous epithelial cells, Suprabasal keratinocytes)

Immune cell specificity

Group enriched (neutrophil, eosinophil)

Cell line specificity

Low cell line specificity

Interaction

Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.

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