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KRT16
Anti-KRT16 Recombinant Antibody Products
- Mouse Anti-KRT16 Recombinant Antibody (VS3-FY2753) (VS3-FY2753)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IHC
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- Anti-KRT16 Immunohistochemistry Kit (VS-0325-XY1211)
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- Species Reactivity: Human, Mouse, Rat
- Target: KRT16
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Suprabasal keratinocytes, Basal keratinocytes, Basal prostatic cells, Urothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (hTCEpi)
Interaction
Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TCHP (PubMed:15731013). Interacts with TRADD (By similarity).
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