KSR1

Recombinant Antibody Products Formats

Anti-KSR1 Recombinant Antibody Products

Recombinant Mouse anti-Human KSR1 Monoclonal antibody (N200) (MOB-2303CT)
- Species Reactivity: Human
- Application: ELISA, IP, WB
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Rabbit Anti-KSR1 Recombinant Antibody (clone R05-4F7) (VS3-XY3414)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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Hi-Affi™ Recombinant Rabbit Anti-KSR1 Monoclonal Antibody (DS1998AB) (MOR-1998)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, WB
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For Research Use Only. Not For Clinical Use.

Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer.

Protein class

Enzymes, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Oligodendrocyte precursor cells, Glandular and luminal cells, Inhibitory neurons, Oligodendrocytes)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Cell line enhanced (HDLM-2, HEL, HMC-1)

Interaction

Homodimer (PubMed:29433126). Heterodimerizes (via N-terminus) with BRAF (via N-terminus) in a MAP2K1/MEK1 or MAP2K2/MEK2-dependent manner (PubMed:29433126). Interacts with MAP2K1/MEK1 and MAP2K2/MEK2 (PubMed:10409742, PubMed:29433126). Binding to MAP2K1/MEK1 releases the intramolecular inhibitory interaction between KSR1 N-terminus and kinase domains which is required for the subsequent RSK1 dimerization with BRAF (PubMed:29433126). Identified in a complex with AKAP13, MAP2K1 and BRAF (By similarity). Interacts with AKAP13 and BRAF (PubMed:21102438). Interacts with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). Interacts with 14-3-3 proteins including YWHAB (By similarity). Interacts with HSP90AA1/HSP90, YWHAE/14-3-3 and CDC37 (PubMed:10409742, PubMed:29433126). The binding of 14-3-3 proteins to phosphorylated KSR1 prevents the membrane localization (By similarity). Interacts with MARK3 (By similarity). Interacts with PPP2R1A and PPP2CA (By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487).

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

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