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Anti-LILRB2 Recombinant Antibody Products

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Anti-LILRB2 Products

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For Research Use Only. Not For Clinical Use.


Designed for optimal precision and dependability, Creative Biolabs provides a large spectrum of highly performing recombinant antibodies targeting LILRB2. These antibodies allow strong and repeatable results by using contemporary engineering techniques to offer better stability and specificity. This makes them vital instruments for researchers and developers striving to progress focused cancer treatments since they enable the identification and creation of creative therapeutic approaches.

LILRB2: An Attractive Target for Cancer Therapy

Found on myeloid cells, LILRB2 mediates immunosuppression in cancer, causes neurodegeneration by interacting with β-amyloid and myelin inhibitors in Alzheimer's, and helps to dysregulate immune responses in autoimmune diseases including SLE and RA. Its capacity to kill immune cells qualifies it as a potential therapeutic target in several types of diseases.

Alternative Names

Leukocyte immunoglobulin-like receptor subfamily B member 2; ILT4, MIR10, LIR2, MIR-10, LIR-2, leukocyte immunoglobulin like receptor B2, ILT-4, CD85D.

Background

LILRB2 encodes an immune receptor that plays a role in immune regulation, particularly in inhibiting immune cell activation. This receptor is involved in controlling the activation of monocytes and dendritic cells, helping to prevent excessive immune responses and autoimmunity. LILRB2 is part of a broader family of immunoglobulin-like receptors that regulate immune tolerance and inflammation. It plays a significant role in maintaining a balance between immunity and tolerance in various diseases, including cancer and autoimmune disorders.

Protein class

CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Kupffer cells, Macrophages, monocytes, Langerhans cells)

Immune cell specificity

Group enriched (non-classical monocyte, intermediate monocyte, neutrophil, classical monocyte)

Cell line specificity

Not detected

Interaction

Binds PTPN6 when phosphorylated. Binds FCGR1A. Interacts with peptide-bound HLA-G-B2M; this interaction is direct (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M; this interaction is direct (PubMed:11169396).

Molecular function

Receptor

More Types Infomation

Anti-LILRB2 rAb Products

Creative Biolabs provides a rigorously designed array of recombinant anti-LILRB2 antibodies developed for excellent specificity and affinity, meeting a wide range of research demands. Our antibodies are produced based on a robust platform and have become cutting-edge tools that speed up scientific discovery and make it easier to develop novel therapies.

Table 1. Featured anti-LILRB2 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
NEUT-1697CQ Recombinant Mouse Anti-LILRB2 Antibody (CBL608) Human Mouse IgG2a WB, FC, Neut, etc.
VS-0723-WK76 Human Anti-LILRB2 Recombinant Antibody (VS-0723-WK76) Human Human Chimeric (rabbit/human) IgG1 FC
VS-0723-WK22 Human Anti-LILRB2 Recombinant Antibody (VS-0723-WK22) Human Human IgG4 ELISA, FC
VS-0225-XY159 CytoStream™ Mouse Anti-LILRB2 Recombinant Antibody (clone 287219) Human Mouse IgG2a, kappa FC
MOB-1097CT Recombinant Mouse anti-Human LILRB2 Monoclonal antibody (EML1069) Human Mouse WB

Creative Quality Control

To guarantee the dependability of its anti-LILRB2 recombinant antibodies, Creative Biolabs applies rigorous quality control all throughout the manufacturing process. Rigorous testing and validation methods confirm the remarkable selectivity, high binding affinity, and optimal performance of our antibodies over a broad spectrum of research uses, therefore guaranteeing consistent and accurate results.

Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-LILRB2 antibody
(Cat# NEUT-1697CQ, Creative Biolabs).

Customer Reviews

Excellent
Le***s
Recombinant Mouse Anti-LILRB2 Antibody (CBL608) (NEUT-1697CQ)
Excellent findings came from our lab's neutralising experiments employing anti-LILRB2 recombinant antibody from Creative Biolabs. Highly consistent and dependable findings came from the antibody's amazing sensitivity and strong LILRB2 inhibiting action. The higher affinity and homogeneity of this antibody greatly simplified our experimental procedure. Their customer service staff also answered our technical questions rather effectively and quickly.
20/Apr/2023
Excellent
Wa***r
Human Anti-LILRB2 Recombinant Antibody (VS-0723-WK22) (VS-0723-WK22)
Our results on the anti-LILRB2 recombinant antibody from Creative Biolabs in flow cytometry and ELISA were first-rate. The great, specific signal and low background of the antibody in ELISA highlighted its great affinity. In flow cytometry, it delivered sharp, well-defined cell separation, simplifying our data analysis. The remarkable consistency observed between these two assays solidified our confidence in the antibody's reliability. The comprehensive product information and the responsive, expert assistance from Creative Biolabs further enhanced our satisfaction. This antibody has become an indispensable tool in our LILRB2 research, and we wholeheartedly recommend it for those requiring a versatile, high-quality reagent for both ELISA and FC applications.
8/Aug/2024

rAb Production

Creative Biolabs provides consistent antibody production for worldwide clients by using creative and effective recombinant antibody producing technologies.

Featured Anti-LILRB2 Recombinant Antibody Production PlatformsFig.2 Milligram-scale. (Creative Biolabs Original)
Fig.2 Milligram-scale anti-LILRB2 recombinant antibody production.

Fig.3 Gram-scale. (Creative Biolabs Original)Fig.3 Gram-scale anti-LILRB2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers a large range of premium anti-LILRB2 recombinant antibodies, carefully engineered in several forms to satisfy the needs of scientists all over.

Fig.4 LILRB2 antibody production and modalities. (Creative Biolabs Original)Fig.4 Full-length anti-LILRB2 recombinant antibody production and modalities.

LILRB2-Targeted Drug Information

Table 2. Public drug targeting LILRB2.

Company Research phase Classification Condition
Agenus (Originator)
Merck & Co
Merck & Co. (Merck & Co)
Phase II Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, colorectal (adenocarcinoma)
Cancer, kidney (renal cell carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, lung (small cell) (SCLC) (extensive)
Cancer, ovary
Cancer, solid tumor
Esophageal carcinoma (squamous cell)
Melanoma
OncoResponse (Originator) Phase I/II Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, solid tumor
NGM Biopharmaceuticals (Originator) Phase I/II Bispecific Antibodies
Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, colorectal
Cancer, solid tumor
Celgene
Jounce Therapeutics (Originator)
Phase I/II Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Cancer, biliary
Cancer, head and neck (squamous cell carcinoma)
Cancer, kidney (renal cell carcinoma, clear cell)
Cancer, lung (non-small cell) (NSCLC)
Cancer, ovary
Cancer, skin
Cancer, solid tumor
Sarcoma
Triple negative breast cancer
SparX Biopharmaceutical (Originator) Phase I Bispecific Antibodies
Cancer Immunotherapy
Cancer, colorectal
Cancer, head and neck (squamous cell carcinoma)
Cancer, kidney (renal cell carcinoma)
Cancer, solid tumor
Elpiscience BioPharma (Originator) Phase I Cancer Immunotherapy
Monoclonal Antibodies
Cancer, solid tumor
Bristol-Myers Squibb (Originator) Phase I Cancer Immunotherapy
Monoclonal Antibodies
Cancer, solid tumor
Biosion (Originator)
Celldex Therapeutics (Originator)
Phase I Bispecific Antibody Fusions
Cancer Immunotherapy
Humanized Monoclonal Antibodies
Single-Chain V-Domain Antibody Fragment (scFv)
Cancer, solid tumor
ImmunOs Therapeutics (Originator) Phase I Biotechnology Medicines
Cancer Immunotherapy
Cancer, solid tumor
Hematologic-blood cancer

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Please reach out to us at your convenience for further details or to request information regarding our anti-LILRB2 recombinant antibody offerings.

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