LLGL1
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Loading...- Anti-LLGL1 Immunohistochemistry Kit (VS-0525-XY4047)
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- Species Reactivity: Human
- Target: LLGL1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Lethal (2) Giant larval protein homolog 1 is a protein encoded by the LLGL1 gene in humans.
The protein encoded by this gene is similar to the tumor suppressor in Drosophila. The protein is part of the cytoskeletal network and is related to the non-muscle myosin II heavy chain and a kinase that specifically phosphorylates the protein on serine residues. This gene is located in the region of Smith-Magenis syndrome on chromosome 17.
The protein encoded by this gene is similar to the tumor suppressor in Drosophila. The protein is part of the cytoskeletal network and is related to the non-muscle myosin II heavy chain and a kinase that specifically phosphorylates the protein on serine residues. This gene is located in the region of Smith-Magenis syndrome on chromosome 17.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interacts with STX4A (By similarity). Interacts with RAB10 (GDP-bound form); the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with DCAF1.
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