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MADD
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.
Protein class
Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Horizontal cells, Cone photoreceptor cells, Rod photoreceptor cells, Bipolar cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts (via death domain) with TNFRSF1A (via death domain) (PubMed:9115275, PubMed:11577081). Interacts with PIDD1 (PubMed:10825539). Interacts with YWHAZ (PubMed:16959763). Interacts (via death domain) with KIF1B (By similarity). Interacts with KIF1A (By similarity). Interacts (via uDENN domain) with RAB3A, RAB3B, RAB3C and RAB3D; the GTP-bound form of the Rab proteins is preferred for interaction (By similarity).
Molecular function
Guanine-nucleotide releasing factor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF
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For Research Use Only. Not For Clinical Use.