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MAP2K7
Loading...Anti-MAP2K7 Products
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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- Mouse Anti-MAP2K7 Recombinant Antibody (clone 4E5) (VS3-XY1030)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
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- AbPlus™ Anti-MAP2K7 Magnetic Beads (VS-0724-YC1146) (VS-0724-YC1146)
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- Target: MAP2K7
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IP, IF, IHC, ELISA
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- Recombinant Mouse Anti-Human MAP2K7 Antibody (MOB-1462MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, ICC, FC, IHC-P
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- Anti-MAP2K7 Immunohistochemistry Kit (VS-0525-XY4214)
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- Species Reactivity: Human
- Target: MAP2K7
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation. Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAPK8IP1/JIP1 and MAPK8/JNK1. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAPK8IP1/JIP1, MAPK8/JNK1 and MAPK9/JNK2 (By similarity).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
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