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MAP3K3

Anti-MAP3K3 Products
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
- Rabbit Anti-MAP3K3 Recombinant Antibody (VS3-WK1121) (VS3-WK1121)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC/IF, IHC-P, IP, WB
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For Research Use Only. Not For Clinical Use.
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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