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MKRN2

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Late spermatids, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with PDLIM2 (via LIM zinc-binding domain) (By similarity). Interacts with RELA (By similarity).

Molecular function

Transferase

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