Anti-MMACHC Products

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For Research Use Only. Not For Clinical Use.

Partner with Creative Biolabs in metabolic and rare disease research. Our award-winning anti-MMACHC recombinant antibodies are designed for use in diagnostics and research exploring vitamin B12 metabolism. Methylmalonyl CoA homocysteine (MMCHC) is a key enzyme in the vitamin B12 metabolic pathway responsible for converting B12 into its two active cofactor forms. Our quality control tested anti-MMACHC antibodies are precision tools for deciphering the intricate biochemistry of B12 metabolism and for research related to methylmalonic aciduria (MMA), cblC type diagnosis.

MMACHC: A Key Enzyme in Vitamin B12 Activation

MMACHC (Methylmalonic Aciduria, cblC Type) is a cytosolic enzyme that catalyzes the first, rate-limiting steps in the activation of dietary vitamin B12 (cobalamin) to its two active cofactor forms, adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). MMACHC enzyme acts by removing side groups from cobalamin to make the vitamin available to the other enzymes that convert it to its active cofactor forms. Mutations in the MMACHC gene cause the most common form of an inherited disorder known as methylmalonic aciduria (MMA), cblC type, resulting in toxic accumulation of MMA, as well as homocysteinemia that leads to severe neurological and hematological damage.

Alternative Names

CblC; cyanocobalamin reductase; alkylcobalamin dealkylase; alkylcobalamin:glutathione S-alkyltransferase; cyanocobalamin reductase (cyanide-eliminating); methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; methylmalonic aciduria and homocystinuria type C protein; EC 1.16.1.6; EC 2.5.1.151

Background

MMACHC (Metabolism Of Cobalamin Associated C) is a Protein Coding gene. Its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Cobalamin (vitamin B12) cytosolic chaperone catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide. Diseases associated with MMACHC include Methylmalonic Aciduria And Homocystinuria, Cblc Type and Disorders Of Intracellular Cobalamin Metabolism.

Anti-MMACHC rAb Products

Creative Biolabs’ recombinant antibodies against MMACHC are engineered to high standards of specificity and performance, with each lot stringently validated for the detection of the MMACHC enzyme. Optimized for use in Western Blot to confirm a cblC diagnosis in patient fibroblasts and for IHC studies, our recombinant antibodies (rAbs) are highly reliable tools for conducting metabolic research.

Table 1. Featured anti-MMACHC recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs supports metabolic disease research and diagnostics with antibody solutions made on leading-edge production platforms. Our anti-MMACHC recombinant antibodies are expressed in systems optimized for antibodies with unmatched specificity and activity that precisely target this cytosolic enzyme.

Featured Anti-MMACHC Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-MMACHC recombinant antibody production.

Fig.2 Gram-scale anti-MMACHC recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating scientific exploration by providing a full spectrum of flexible antibody modalities. Our anti-MMACHC recombinant antibodies are available in a variety of customizable formats to fit your research needs.

Fig.3 Full-length anti-MMACHC recombinant antibody production and modalities.

Cut through the complexities of vitamin B12 metabolism with Creative Biolabs’ high-performance anti-MMACHC recombinant antibodies. From unrivaled specificity to the validation and consistency needed to study this essential enzyme or work on methylmalonic aciduria diagnosis, our products form a strong foundation for your research. Contact our science team today to learn more.