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MMAF (with VC-PAB Linker)
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For Research Use Only. Not For Clinical Use.
Background
Monomethyl auristatin F (MMAF) with the Mc-VC-PAB linker is a potent cytotoxic compound that inhibits cell division by blocking tubulin polymerization, leading to the disruption of microtubule dynamics. This mechanism of action allows MMAF to effectively target and kill rapidly dividing cancer cells.
The addition of the Mc-VC-PAB linker further enhances the specificity and efficacy of MMAF by allowing for targeted delivery to tumor cells. The linker is stable in extracellular fluid but is cleaved by cathepsin B once inside the tumor cell, activating the antimitotic mechanism and increasing the potency of MMAF against cancer cells.
In addition to its anticancer activity, MMAF also exhibits antioxidant, anti-inflammatory, and insecticidal activities, making it a versatile compound with a range of potential therapeutic applications.
The addition of the Mc-VC-PAB linker further enhances the specificity and efficacy of MMAF by allowing for targeted delivery to tumor cells. The linker is stable in extracellular fluid but is cleaved by cathepsin B once inside the tumor cell, activating the antimitotic mechanism and increasing the potency of MMAF against cancer cells.
In addition to its anticancer activity, MMAF also exhibits antioxidant, anti-inflammatory, and insecticidal activities, making it a versatile compound with a range of potential therapeutic applications.