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Mrc2

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Fibroblasts, Peritubular cells, Early spermatids, Late spermatids, Leydig cells, Theca cells, Endometrial stromal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, fHDF/TERT166, HSkMC, hTERT-RPE1, U-138 MG)

Interaction

Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.

Molecular function

Receptor

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