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Mrc2
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Fibroblasts, Peritubular cells, Early spermatids, Late spermatids, Leydig cells, Theca cells, Endometrial stromal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166, HSkMC, hTERT-RPE1, U-138 MG)
Interaction
Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.
Molecular function
Receptor
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv fragment
- Mouse Anti-MRC2 Recombinant Antibody; scFv Fragment (TAB-0831CL-S(P)) (TAB-0831CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0694-YC) (HPAB-M0694-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) (HPAB-M0693-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0692-YC) (HPAB-M0692-YC)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, FuncS
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- Species Reactivity: Mouse
- Type: Llama VHH
- Application: WB, ELISA, IP, FuncS
- Mouse Anti-MRC2 Recombinant Antibody; scFv Fragment (HPAB-M0694-YC-S(P)) (HPAB-M0694-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody; scFv Fragment (HPAB-M0693-YC-S(P)) (HPAB-M0693-YC-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody; scFv Fragment (HPAB-M0692-YC-S(P)) (HPAB-M0692-YC-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody; Fab Fragment (TAB-0831CL-F(E)) (TAB-0831CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-MRC2 Recombinant Antibody; Fab Fragment (TAB-0830CL-F(E)) (TAB-0830CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-MRC2 Recombinant Antibody (TAB-0831CL) (TAB-0831CL)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-MRC2 Recombinant Antibody; scFv Fragment (TAB-0830CL-S(P)) (TAB-0830CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-MRC2 Recombinant Antibody; Fab Fragment (HPAB-M0694-YC-F(E)) (HPAB-M0694-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody; Fab Fragment (HPAB-M0693-YC-F(E)) (HPAB-M0693-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, FuncS
- Mouse Anti-MRC2 Recombinant Antibody; Fab Fragment (HPAB-M0692-YC-F(E)) (HPAB-M0692-YC-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: WB, FuncS
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For Research Use Only. Not For Clinical Use.