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MYBBP1A
Anti-MYBBP1A Recombinant Antibody Products
- Mouse Anti-MYBBP1A Recombinant Antibody (VS3-WK1130) (VS3-WK1130)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Anti-MYBBP1A Immunohistochemistry Kit (VS-0325-XY1399)
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- Species Reactivity: Human, Mouse, Rat
- Target: MYBBP1A
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants.
Protein class
Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.
Molecular function
Activator, Repressor
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