Mycobacterium tuberculosis Ag85C

Mycobacterium tuberculosis Ag85C is another vital protein in the Ag85 family of Mycobacterium tuberculosis, sharing structural homology with Ag85A and Ag85B but with unique functional nuances. Like other Ag85 members, it contributes to bacterial cell wall synthesis by aiding in mycolic acid cross-linking, which is crucial for the bacterium's survival and resistance to host defenses. Ag85C has distinct immunogenic properties; it can trigger specific immune responses in the host, including the activation of cytotoxic T cells that target infected cells. Its conservation across most Mycobacterium tuberculosis strains makes it a valuable candidate for broad-spectrum tuberculosis vaccines. It also serves as a potential diagnostic marker, as its presence or the host's immune response to it can indicate active tuberculosis infection, complementing other diagnostic tools.