Myofibroblast / Fibrosis
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For Research Use Only. Not For Clinical Use.
Background
Myofibroblasts are a distinctive cell type characterized by features intermediate between fibroblasts and smooth muscle cells. These versatile cells play a pivotal role in tissue repair, wound healing, and crucially, in the pathological process of fibrosis. They are identified by their robust contractile machinery, including the expression of α-smooth muscle actin (α-SMA, encoded by ACTA2), and their vigorous capacity to synthesize and remodel extracellular matrix (ECM) components, particularly Collagen I and