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NCF2
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (monocytes, Hofbauer cells, Macrophages, Kupffer cells, Langerhans cells, Ductal cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (A-431, HMC-1, hTERT-HME1, RPMI-8226, U-2 OS)
Interaction
Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF4. Interacts (via the C-terminal SH3 domain) with NCF1 (via C-terminus). Interacts with SYTL1 and RAC1. May interact with NOXO1. Interacts with S100A8 and calprotectin (S100A8/9) (PubMed:15642721). Interacts with GBP7 (via GB1/RHD3-type G domain) (By similarity). Interacts with CYBB; the interaction is enhanced in the presence of GBP7 (By similarity).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC, IHC-P, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.