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NCL
Anti-NCL Recombinant Antibody Products
- Recombinant Rabbit Anti-NCL Antibody (clone R08-6H3) (VS3-FY1010)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Recombinant Anti-human NCL Antibody (MOB-693)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IF, FuncS
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- Rabbit Anti-NCL Polyclonal Antibody (MRO-2089-CN) (MRO-2089-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF
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- Rabbit Anti-NCL Polyclonal Antibody (MRO-2090-CN) (MRO-2090-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Human Anti-NCL Recombinant Antibody (HPAB-M0579-YC) (HPAB-M0579-YC)
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- Species Reactivity: Human
- Type: Human IgG, κ
- Application: ELISA, WB, FuncS
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- Human Anti-NCL Recombinant Antibody; scFv Fragment (HPAB-M0579-YC-S(P)) (HPAB-M0579-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FuncS
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- Recombinant Anti-human NCL Antibody Fab Fragment (MOB-693-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, Neut, FuncS
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- Recombinant Anti-human NCL Antibody scFv Fragment (MOB-693-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
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- Recombinant Human Anti-human NCL Antibody Fab Fragment (MHH-693-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, IF, FuncS
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- Recombinant Human Anti-human NCL Antibody scFv Fragment (MHH-693-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, IP, FuncS
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- Human Anti-NCL Recombinant Antibody; Fab Fragment (HPAB-M0579-YC-F(E)) (HPAB-M0579-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FuncS
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- Anti-NCL Immunohistochemistry Kit (VS-0325-XY1463)
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- Species Reactivity: Human, Mouse
- Target: NCL
- Application: IHC
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- Rabbit Anti-NCL Recombinant Antibody (VS13-YC770) (VS13-YC770)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P
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For Research Use Only. Not For Clinical Use.
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70 (By similarity). Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin (PubMed:10393184). Interacts with AICDA (By similarity). Interacts with APTX (PubMed:15044383). Interacts with C1QBP (PubMed:21536856). Interacts with ERBB4 (PubMed:20858735). Interacts (via C-terminus) with FMR1 isoform 6 (via N-terminus) (PubMed:24658146). Interacts with GZF1; this interaction is important for nucleolar localization of GZF1 (PubMed:17674968). Interacts with NSUN2 (PubMed:17215513). Interacts with NVL (PubMed:21474449). Interacts (via N-terminus domain) with SETX (PubMed:21700224). Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT (PubMed:15371412). Interacts with WDR46 (PubMed:23848194). Interacts with ZFP36 (PubMed:20221403). Interacts with LRRC34 (By similarity). Interacts with RRP1B (PubMed:19710015). Interacts with HNRNPU; this interaction occurs during mitosis (PubMed:21242313). Interacts with RIOK1; RIOK1 recruits NCL to PRMT5 for symmetrically methylation (PubMed:21081503). Interacts with ZBTB7B (By similarity). Interacts with MDK; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (PubMed:12147681). Interacts with HDGF (isoform 1) (PubMed:26845719). Interacts with ALKBH2.
Molecular function
DNA-binding, RNA-binding
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