NDUFAF1

AbPlus Recombinant Antibody Products Formats

Anti-NDUFAF1 Recombinant Antibody Products

Rabbit Anti-NDUFAF1 Recombinant Antibody (clone JE47-18) (VS3-WK373)
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IHC, FC
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Rabbit Anti-NDUFAF1 Recombinant Antibody (clone R04-2J6) (VS3-FY1787)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF, IP
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Anti-NDUFAF1 Immunohistochemistry Kit (VS-0325-XY1471)
- Species Reactivity: Human, Mouse, Rat
- Target: NDUFAF1
- Application: IHC
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Hi-Affi™ Recombinant Rabbit Anti-NDUFAF1 Monoclonal Antibody (DS2399AB) (MOR-2399)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC, IHC-P, IP, WB
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For Research Use Only. Not For Clinical Use.

This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19.

Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Spermatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186 (PubMed:32320651). Interacts with ECSIT (PubMed:17344420). Interacts with ACAD9 (PubMed:20816094). At early stages of complex I assembly, it is found in intermediate subcomplexes that contain different subunits including NDUFB6, NDUFA6, NDUFA9, NDUFS3, NDUFS7, ND1, ND2 and ND3 (PubMed:17557076). Interacts with TMEM70 and TMEM242 (PubMed:33753518).

Molecular function

Chaperone

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