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NEUROD1
Loading...Anti-NEUROD1 Products
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Mouse Anti-NEUROD1 Recombinant Antibody (clone 3H2) (VS3-XY1156)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-NEUROD1 Recombinant Antibody (clone 6E6) (VS3-XY1157)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IP, WB
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- Mouse Anti-NEUROD1 Recombinant Antibody (clone 4G12B4) (VS7-0425-WR465)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, FC
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- Mouse Anti-NEUROD1 Recombinant Antibody (clone 8C4H4) (VS7-0425-WR466)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Mouse Anti-NEUROD1 Monoclonal Antibody (clone 6E9G12) (VS7-0425-WR467)
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- Species Reactivity: Human, Mouse, Monkey
- Type: Mouse IgG1
- Application: WB, ELISA
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- Anti-NEUROD1 Immunohistochemistry Kit (VS-0525-XY4797)
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- Species Reactivity: Human
- Target: NEUROD1
- Application: IHC
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- Anti-Mouse NEUROD1 Immunohistochemistry Kit (VS-0525-XY4798)
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- Species Reactivity: Human, Mouse
- Target: NEUROD1
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Rod photoreceptor cells, Cone photoreceptor cells, Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Efficient DNA-binding requires dimerization with another bHLH protein (By similarity). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element (PubMed:14752053). Interacts with EP300; the interaction is inhibited by NR0B2 (PubMed:14752053). Interacts with RREB1 (PubMed:12482979). Interacts with ATOH8 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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