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NKX2-5
Loading...Anti-NKX2-5 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Recombinant Anti-Mouse NKX2-5 Antibody (MOB-0201MC)
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- Species Reactivity: Human
- Application: ELISA, WB
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- Recombinant Mouse Anti-Human NKX2-5 Antibody (MOB-1726MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-NKX2-5 Recombinant Antibody (clone 2E1) (VS3-XY1167)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-NKX2-5 Monoclonal Antibody (clone 2E1) (VS7-0425-WR483)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Anti-NKX2-5 Immunohistochemistry Kit (VS-0525-XY4857)
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- Species Reactivity: Human
- Target: NKX2-5
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEK93, NTERA-2, SK-MEL-30, U-2 OS, U-251 MG)
Interaction
Homodimer (via the homeobox); binds DNA as homodimer (PubMed:22849347). Interacts (via the homeobox) with TBX5 (via the T-box); this complex binds DNA (PubMed:26926761). Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Interacts with TBX18 (By similarity). Interacts with histone methyltransferase NSD2 (via HMG box) (By similarity).
Molecular function
Developmental protein, DNA-binding
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