Anti-NPR2 Products

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For Research Use Only. Not For Clinical Use.

Partnering with world-class academic and industry researchers in endocrinology and skeletal biology, Creative Biolabs has created some of the most reliable anti-NPR2 recombinant antibodies available. Natriuretic Peptide Receptor 2 (NPR2) is the major receptor for the C-type natriuretic peptide (CNP), and a master regulator of longitudinal bone growth. Creative's high quality recombinant antibodies are the perfect tools to further explore skeletal dysplasias, dwarfism, and possible therapies targeting the CNP signaling pathway.

NPR2: The Critical Receptor for Bone Growth

A single-pass transmembrane receptor also known as guanylate cyclase B, NPR2 is highly expressed in the growth plates of long bones. Activation of NPR2 by its endogenous ligand, C-type natriuretic peptide (CNP) leads to production of the second messenger cGMP. The CNP-NPR2-cGMP pathway is the most robust endogenous stimulator of endochondral ossification, the cellular process responsible for the growth of bones in length. Loss-of-function mutations in the NPR2 gene result in Acromesomelic Dysplasia, Maroteaux type (AMDM), a form of dwarfism, further characterizing NPR2 as a hot-spot for skeletal diseases.

Alternative Names

NPR2; GUCY2B; Natriuretic Peptide Receptor B/Guanylate Cyclase B (Atrionatriuretic Peptide Receptor B); Atrial Natriuretic Peptide Receptor 2; ECDM; Atrial Natriuretic Peptide Receptor Type B; ANPR-B; Atrial Natriuretic Peptide B-Type Receptor; NPRB; ANPb

Background

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Anti-NPR2 rAb Products

Creative Biolabs' anti-NPR2 recombinant antibodies are designed for optimal performance in all of your experiments. These antibodies have been shown to have high specificity and affinity for this important receptor, allowing precise, reproducible quantification of NPR2 in chondrocytes and other target cells. Validated for use in a variety of applications including flow cytometry and IHC, these rAbs can give you the accurate readouts you need for high-impact endocrinology research.

Table 1. Featured anti-NPR2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs' advanced production technologies create our premium anti-NPR2 recombinant antibodies. Using optimized mammalian expression systems, we produce recombinant antibodies which correctly recognize the extracellular domain of the native receptor, resulting in a highly specific and functional product for all of your most demanding applications.

Featured Anti-NPR2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-NPR2 recombinant antibody production.

Fig.2 Gram-scale anti-NPR2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers a suite of anti-NPR2 recombinant antibody modalities to meet all of your skeletal research needs. We offer customizable antibody formats, including full-length IgGs for use in functional activation or blocking studies, and Fab fragments for structural biology, to support researchers around the world.

Fig.3 Full-length anti-NPR2 recombinant antibody production and modalities.

Move your research on skeletal growth, dwarfism, and possible therapies for these conditions forward with Creative Biolabs' highly validated anti-NPR2 recombinant antibodies. Rigorous validation, and unsurpassed lot-to-lot consistency makes our suite of anti-NPR2 rAbs the ideal set of tools for studying this important receptor pathway. Trust the quality of Creative Biolabs and contact our scientific team today.