NTHL1
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Loading...- Anti-NTHL1 Immunohistochemistry Kit (VS-0525-XY5010)
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- Species Reactivity: Human
- Target: NTHL1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with YBX1 (By similarity) (PubMed:11287425). Interacts with ERCC5/XPG; the interaction stimulates NTHL1 activity and NTHL1 binding to its DNA substrate (PubMed:9927729).
Molecular function
Glycosidase, Hydrolase, Lyase
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