Anti-PCYT1A Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs has partnered with you for research in lipid metabolism by developing high specific anti-PCYT1A recombinant antibodies. As the rate-limiting enzyme for the CDP-choline pathway, CTP: Phosphocholine Cytidylyltransferase Alpha (PCYT1A) tightly regulates phosphatidylcholine synthesis. Our premium antibodies will be the key to studying its intricate regulation and function in liver disease, macrophage biology, and cancer.

PCYT1A: The Rate-Limiting Enzyme for PC Synthesis

CTP: Phosphocholine Cytidylyltransferase Alpha (PCYT1A) is the rate-limiting enzyme in the de novo pathway of phosphatidylcholine (PC) synthesis. PC is the most abundant phospholipid in cell membranes. PCYT1A transfers the cytidylyl group from CTP to phosphocholine to generate CDP-choline. This is the rate-limiting step of the entire pathway. It is under tight control and is only active when it senses that more membrane is needed. It does so by binding to PC-deficient membranes like the nuclear envelope and the endoplasmic reticulum (ER). The enzyme exists as an active membrane-bound form and an inactive soluble dimer that resides in the nucleus. It is only active as a membrane-bound heterodimer. In this way, the enzyme is a key metabolic sensor for membrane biogenesis.

Alternative Names

CT; CTA; CCTA; CTPCT; PCYT1; SMDCRD; CCTalpha; choline-phosphate cytidylyltransferase A; CCT A; CCT-alpha; CT A; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase-alpha; choline-phosphate cytidylyltransferase alpha; phosphate cytidylyltransferase 1, choline, alpha; phosphorylcholine transferase A; phosphorylcholine transferase alpha

Background

This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene.

Anti-PCYT1A rAb Products

Creative Biolabs’ anti-PCYT1A recombinant antibodies have been designed to be highly specific and effective in detecting the PCYT1A enzyme. They have been extensively validated to ensure the accurate detection of this key metabolic enzyme. The antibodies are optimized for use in detecting its expression in cellular fractionation studies by Western Blot as well as for immunofluorescence applications to visualize its translocation from the nucleus to the ER.

Table 1. Featured anti-PCYT1A recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs does not cut corners when it comes to science. The development of our anti-PCYT1A recombinant antibodies has been overseen by an exacting quality control system. Every lot of this antibody is tested for purity, specificity and has been shown to work reproducibly in validated applications.

Customer Reviews

rAb Production

Creative Biolabs is at the forefront of antibody production technology to support the highly specialized fields of cell biology research. The anti-PCYT1A recombinant antibodies are produced in optimized systems that express the antibody in a manner that will specifically recognize the native enzyme. This provides you with a highly specific and active research tool.

Featured Anti-PCYT1A Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-PCYT1A recombinant antibody production.

Fig.4 Gram-scale anti-PCYT1A recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to facilitating and supporting scientific research by providing high quality and flexible antibody solutions to investigators. Our anti-PCYT1A recombinant antibodies are available in a variety of formats to meet the needs of your experiments. Allow our antibodies to help you study this important metabolic enzyme worldwide.

Fig.5 Full-length anti-PCYT1A recombinant antibody production and modalities.

Study lipid metabolism with Creative Biolabs’ anti-PCYT1A recombinant antibodies. With thorough validation and lot-to-lot consistency, our antibodies are what you need to study this important metabolic enzyme. Put your research on solid ground and trust Creative Biolabs for this key tool in your research. Reach out to our scientific team today.