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PDE4D

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Astrocytes, Oligodendrocytes)

Immune cell specificity

Immune cell enriched (eosinophil)

Cell line specificity

Cell line enhanced (A549, AN3-CA, HeLa)

Interaction

Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind RACK1 via their unique N-terminus. Binds ARRB2. Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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