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Anti-PDE4D Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Creative Biolabs is dedicated to delivering premium recombinant antibodies engineered to target PDE4D, actively supporting and driving forward advancements in biomedical research. By harnessing cutting-edge technological platforms, we ensure our products adhere to rigorous quality and performance standards, providing researchers with robust tools to propel their work. Our extensive portfolio of recombinant solutions underscores our commitment to offering dependable, high-value reagents tailored to diverse research needs. Beyond our top-quality antibodies, we provide comprehensive, customized technical support designed to guide researchers at every stage of their projects, fostering a collaborative environment for success. Collaborating with Creative Biolabs means gaining access to innovative research tools and a dedicated partner committed to being an integral part of your scientific journey, combining excellence in both products and service to advance your pursuits.
PDE4D: A Crucial target in Autoimmune Disorders and Inflammatory Diseases
PDE4D is a crucial enzyme responsible for breaking down cyclic AMP (cAMP), a key signaling molecule that regulates numerous cellular functions including inflammation, neural activity, and immune responses. Dysregulation of PDE4D has been linked to various diseases, particularly those involving the nervous system and inflammatory processes. Elevated PDE4D activity is associated with neuropsychiatric disorders such as depression, schizophrenia, and cognitive impairments, where altered cAMP signaling disrupts neuronal communication and plasticity. Inflammatory conditions like chronic obstructive pulmonary disease (COPD), asthma, and psoriasis also show increased PDE4D expression, contributing to excessive inflammatory responses and tissue damage. Additionally, PDE4D has been implicated in cardiovascular diseases and certain cancers, where it influences cell proliferation, migration, and survival pathways. Due to its broad involvement in disease mechanisms, PDE4D is considered a promising therapeutic target. Several PDE4 inhibitors that modulate PDE4D activity have been developed or are in clinical use to manage inflammatory and neurological disorders. Ongoing research continues to explore PDE4D's role in disease and aims to develop more selective and effective treatments to improve patient outcomes across multiple clinical areas.
Alternative Names
Complement cAMP-specific 3',5'-cyclic phosphodiesterase 4D; EC 3.1.4.53; DPDE3; PDE43; PDE4D; DPDE3
Background
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Astrocytes, Oligodendrocytes)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enhanced (A549, AN3-CA, HeLa)
Interaction
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind RACK1 via their unique N-terminus. Binds ARRB2. Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.
Molecular function
Hydrolase
More Types Infomation
Anti-PDE4D rAb Products
Our goal is to accelerate research and innovation by providing high-quality anti-PDE4D recombinant antibodies that deliver exceptional value and reliable technical support.
Table 1. Featured anti-PDE4D recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| ZG-0030U | Rabbit Anti-PDE4D Recombinant Antibody (clone 4D4) | Human | Rabbit | ELISA; WB |
| MOR-2632 | Hi-Affi™ Recombinant Rabbit Anti-PDE4D Monoclonal Antibody (DS2632AB) | Human | Rabbit | WB |
Creative Quality Control
To facilitate the progression of biopharmaceutical research all the way to successful commercialization, we focus on a client-oriented strategy that emphasizes delivering superior-quality products. Our comprehensive quality management system guarantees consistent excellence in every product. By surpassing client expectations, we aim to support and accelerate their drug development schedules and overall project success.
Fig.1 WB analysis of anti-PDE4D antibody (Cat# ZG-0030U, Creative Biolabs).
Customer Reviews
Excellent
B**onRabbit Anti-PDE4D Recombinant Antibody (clone 4D4) (CAT#: ZG-0030U)
We used the Rabbit Anti-PDE4D Recombinant Antibody in ELISA assays with human lung tissue samples. The antibody showed strong specificity and consistent sensitivity, providing clear and reproducible results. It performed well under standard assay conditions without requiring extensive optimization. Overall, it proved to be a reliable antibody for detecting PDE4D in our ELISA experiments.
17/Oct/2024
Excellent
Ju**nRabbit Anti-PDE4D Recombinant Antibody (clone 4D4) (CAT#: ZG-0030U)
In our Western blot experiments using mouse brain tissue lysates, the Rabbit Anti-PDE4D Recombinant Antibody provided clear and specific bands with low background. The antibody consistently detected PDE4D across multiple runs and integrated smoothly into our existing protocols without needing adjustments. It is a dependable option for PDE4D detection in WB applications.
12/Jul/2024
Excellent
N**leHi-Affi™ Recombinant Rabbit Anti-PDE4D Monoclonal Antibody (DS2632AB) (CAT#: MOR-2632)
We tested the Hi-Affi™ Recombinant Rabbit Anti-PDE4D Monoclonal Antibody on human liver tissue lysates using Western blot. The antibody showed strong specificity with distinct bands and minimal background. It performed reliably in repeated tests and fit well into our standard WB workflow without additional optimization. Overall, it's a solid choice for PDE4D detection.
23/Apr/2023
rAb Production
With extensive experience in recombinant antibody development, we consistently provide high-quality products paired with excellent service, ensuring rapid delivery to support your research needs.
Featured Anti-PDE4D Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.
Fig.3 Gram-scale recombinant antibody production.
rAb Modalities
Creative Biolabs is committed to supplying researchers with a comprehensive range of advanced recombinant antibodies available in multiple formats. Our expertise covers diverse engineering techniques, and we provide tailored custom engineering services to meet your unique research demands.
Fig.4 Full Length Anti-PDE4D Recombinant Antibody Production and Modalities.
If you need further information about the PDE4D target, please don't hesitate to contact us by phone or email. Our experienced team is happy to help with any questions or challenges you may face during your experiments, providing the support necessary for successful research.
Related Signaling Pathways
cAMP Signaling Pathway