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PDGFRL
Loading...Anti-PDGFRL Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Anti-PDGFRL Immunohistochemistry Kit (VS-0325-XY1600)
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- Species Reactivity: Human
- Target: PDGFRL
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
Protein class
Disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Fibroblasts, Leydig cells, Peritubular cells, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AN3-CA, BJ hTERT+, HSkMC)
Interaction
Forms a complex composed of PDGFRL, TNK2 and GRB2.
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