PERK
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Loading...- Rabbit Anti-PEK/PERK (phospho T982) Antibody (VS-0126-XL1502)
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- Species Reactivity: Human
- Application: Phospho Antibodies for Cell Signaling Research
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- Rabbit Anti-PERK (phospho T982) Antibody (VS-0126-XL1975)
-
- Species Reactivity: Human; Mouse; Rabbit
- Application: Phospho Antibodies for Cell Signaling Research
Compare
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.