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PHB2
Anti-PHB2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (PubMed:20959514, PubMed:28017329, PubMed:31522117). Interacts with ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703 (PubMed:21328542). Interacts with STOML2 (PubMed:21746876). Interacts with ARFGEF3 (PubMed:19496786). Interacts with SPHK2. Interacts with COX4I1; the interaction associates PHB2 with COX (By similarity). Interacts with MAP1LC3B (membrane-bound form LC3-II); the interaction is direct and upon mitochondrial depolarization and proteasome-dependent outer membrane rupture (PubMed:28017329). Interacts with IGFBP6 (via C-terminal domain) (PubMed:24003225). Interacts with CLPB (PubMed:31522117). Interacts with CD86 (via cytoplasmic domain); the interactions increases after priming with CD40 (By similarity). Interacts with AFG3L2 (By similarity). Interacts with DNAJC19 (By similarity). (Microbial infection) Interacts with SARS coronavirus/SARS-CoV nsp2 protein. (Microbial infection) Interacts with human enterovirus 71/EV-71 capsid protein VP1; the interaction is required for induction of autophagy and the infectivity of EV-71. (Microbial infection) Interaction with human immunodeficiency virus type 1/HIV-1 envelope glycoprotein GP160.
Molecular function
Receptor, Repressor
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