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PHOX2B

Anti-PHOX2B ProductsBackground
Anti-PHOX2B Products
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
- Anti-PHOX2B Immunohistochemistry Kit (VS-0525-XY5379)
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- Species Reactivity: Human
- Target: PHOX2B
- Application: IHC
- Anti-Mouse PHOX2B Immunohistochemistry Kit (VS-0525-XY5380)
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- Species Reactivity: Human, Mouse
- Target: PHOX2B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.