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PKN1
Loading...Anti-PKN1 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-PKN1 Recombinant Antibody (clone 2D7) (VS3-XY1263)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, FC, ICC, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
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- Rabbit Anti-PKN1 Recombinant Antibody (VS13-YC905) (VS13-YC905)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB
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- Mouse Anti-PKN1 Recombinant Antibody (clone 4H10B1) (VS7-0425-WR621)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IHC, ICC, FC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with ZFAND6 (By similarity). Interacts with AR (PubMed:12514133). Interacts with PRKCB (PubMed:20228790). Interacts (via REM 1 and REM 2 repeats) with RAC1 (PubMed:14514689, 18006505). Interacts (via REM 1 repeat) with RHOA (PubMed:10619026, 8571126). Interacts with RHOB (PubMed:9478917). Interacts (via C-terminus) with PDPK1 (PubMed:10792047). Interacts with CCNT2; enhances MYOD1-dependent transcription (PubMed:16331689). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). (Microbial infection) Interacts (via the second REM repeat) with S. typhimurium E3 ubiquitin-protein ligase SspH1 (via the leucine-rich repeat region) (PubMed:16611232, 24248594).
Molecular function
Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase
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