Rabbit Anti-PKN1 Recombinant Antibody (clone R09-2I4) (CAT#: VS3-FY1836)

• Immunogen
• Synthetic peptide of human PKN

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat PKN1

• Species Reactivity
• Human, Rat

• Clone
• R09-2I4

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 104 kDa, while the observed molecular weight stands at 120 kDa.

• Related Disease
• Mevalonic Aciduria and Malignant Acrospiroma

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

• Gene ID
• 5585

• UniProt ID
• Q16512

• Sequence Similarities
• Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus

• Post Translation Modifications
• Autophosphorylated; preferably on serine.
  Phosphorylated during mitosis.
  (Q16512-PKN1_HUMAN)
  Activated by limited proteolysis with trypsin. (Q16512-PKN1_HUMAN)
  (Microbial infection) In case of infection, polyubiquitinated by the bacterial E3 ubiquitin-protein ligase SspH1, leading to its proteasomal degradation. (Q16512-PKN1_HUMAN)
  Glycosylation at Asn154 (NX_Q16512 [NX_Q16512-1])
  Ubiquitination at Lys263 (NX_Q16512 [NX_Q16512-1])
  Modification sites at PhosphoSitePlus (Q16512)
  Glycosylation from GlyConnect PKN1_HUMAN (1737)
  Glycosylation from GlyGen (Q16512) 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

• Protein Refseq
• NP_002732.3; NP_998725.1

• Function
• PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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