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PLA2G3

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease.
Protein class

Enzymes, Metabolic proteins, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Suprabasal keratinocytes, Breast glandular cells, Alveolar cells type 2)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AF22, AN3-CA, NTERA-2, SCLC-21H)

Molecular function

Hydrolase

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