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PLA2G3

Anti-PLA2G3 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, FuncS
- Mouse Anti-PLA2G3 Recombinant Antibody (clone 8G8) (VS-0224-XY101)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease.
Protein class
Enzymes, Metabolic proteins, RAS pathway related proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Breast glandular cells, Alveolar cells type 2)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AF22, AN3-CA, NTERA-2, SCLC-21H)
Molecular function
Hydrolase
More Types Infomation