Anti-PSMC3 Recombinant Antibody Products

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Anti-PSMC3 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides premium-grade recombinant antibodies specifically targeting PSMC3 to accelerate breakthroughs in life science research. Utilizing cutting-edge production methodologies, we ensure every antibody batch meets stringent quality control parameters for optimal experimental reproducibility. Scientists benefit from our diverse range of meticulously engineered antibodies, each delivering exceptional research utility and consistent performance. Beyond supplying these innovative biological tools, our specialists offer personalized consultation services to optimize experimental design and implementation. Partnering with us means gaining access to scientifically validated antibody solutions backed by a team genuinely invested in your research achievements.

PSMC3: A Crucial target in Autoimmune Disorders and Inflammatory Diseases

PSMC3 has emerged as a critical player in various pathological conditions due to its essential role in the ubiquitin-proteasome system. As a key component of the 19S regulatory particle, this ATPase contributes to protein quality control, with its dysfunction linked to neurodegenerative diseases like Parkinson's and Alzheimer's through impaired clearance of misfolded proteins. In cancer biology, PSMC3 demonstrates oncogenic properties, with overexpression observed in multiple malignancies where it promotes cell proliferation and drug resistance by enhancing proteasomal degradation of tumor suppressors. The target also participates in immune regulation, with altered expression patterns affecting antigen presentation in autoimmune disorders. Recent studies connect PSMC3 abnormalities to rare developmental syndromes characterized by intellectual disability and growth retardation, suggesting its importance in neurodevelopment. Viral pathogens, including HIV and hepatitis C, exploit PSMC3-mediated protein degradation for viral replication, highlighting its role in infectious diseases. The enzyme's structural complexity, with multiple functional domains and ATP-binding sites, presents unique opportunities for therapeutic intervention, though challenges remain in developing selective modulators that can precisely target disease-specific proteasomal activities without disrupting global protein homeostasis. Current research focuses on exploiting PSMC3's regulatory mechanisms across these diverse pathological contexts.

Alternative Names

Complement PSMC3; proteasome (prosome, macropain) 26S subunit, ATPase, 3; TBP1; 26S protease regulatory subunit 6A; TBP-1; Tat-binding protein 1; proteasome subunit P50; proteasome 26S subunit ATPase 3; 26S proteasome AAA-ATPase subunit RPT5; human immunodeficiency virus tat transactivator binding protein-1;

Background

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Anti-PSMC3 rAb Products

At Creative Biolabs, we drive biomedical innovation through rigorously validated anti-PSMC3 recombinant antibodies that deliver exceptional specificity, cost-effectiveness, and comprehensive research assistance. Our antibodies enable reproducible experimental results while our specialists provide tailored guidance to optimize study design and maximize research outcomes, ensuring scientists achieve their objectives efficiently.

Table 1. Featured anti-PSMC3 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

Sa**l
Mouse Anti-PSMC3 Recombinant Antibody (clone 30F4) (CAT#: MOB-3087z)

We used the Mouse Anti-PSMC3 Recombinant Antibody for flow cytometry on Jurkat cells. The antibody produced a clear signal with low background, and the staining pattern was consistent across replicates. It required minimal adjustment to our standard FC protocol. Overall, it performed well and proved to be a reliable reagent for PSMC3 detection.

15/Mar/2024

Excellent

N**an
Mouse Anti-NHP PSMC3 Recombinant Antibody (clone OTI1C10) (CAT#: VS-1024-XY420)

In our Western blot tests, we used the Mouse Anti-NHP PSMC3 Recombinant Antibody with lysates from COS-7 cells. The antibody showed a strong, specific band at the expected size and minimal non-specific binding. It integrated smoothly into our workflow and produced consistent results. A dependable option for WB applications in non-human primate samples.

21/Jun/2024

Excellent

Gr**e
Mouse Anti-PSMC3 Recombinant Antibody (clone 1G10B7) (CAT#: VS7-0425-WR705)

We applied the Mouse Anti-PSMC3 Recombinant Antibody in Western blot using lysates from HeLa cells. The antibody produced a distinct band at the correct molecular weight with low background. It worked well under standard conditions and didn’t require much optimization. Overall, it's a reliable reagent for WB analysis.

20/Sep/2023

rAb Production

Drawing on deep expertise in recombinant antibody development and optimization, we prioritize delivering high-quality products with both speed and reliability at the forefront. Our team’s unwavering commitment to exceptional service ensures that researchers consistently receive dependable antibody solutions in a prompt and efficient manner, supporting their workflows with precision and timely support.

Featured Anti-PSMC3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs empowers researchers with an extensive portfolio of cutting-edge recombinant antibodies available in versatile configurations to address complex experimental challenges. Our team's mastery of next-generation antibody development techniques allows for the creation of highly adaptable research tools. Every antibody solution is further enhanced by premium bespoke engineering services, meticulously tailored to overcome the specific biological hurdles encountered in your investigations.

Fig.3 Full Length Anti-PSMC3 Recombinant Antibody Production and Modalities.

For comprehensive information regarding the PSMC3 target or technical assistance with your studies, our expert team welcomes your correspondence through either phone or email. We provide customized solutions to address experimental challenges and optimize research outcomes—please don't hesitate to reach out to our specialists for personalized support tailored to advance your scientific investigations effectively.