Anti-PTS Recombinant Antibody Products

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Anti-PTS Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in developing high-performance recombinant antibodies targeting PTS to drive innovative biomedical research. Our advanced antibody engineering platform integrates cutting-edge technologies with rigorous quality assurance, delivering reliable research tools that exceed experimental requirements. We support scientists throughout their projects with tailored solutions, from initial design to final data interpretation, while maintaining competitive pricing and rapid turnaround times. Our team of experts provides personalized guidance to help overcome technical challenges and achieve optimal results in your specific applications.

PTS: A Key Metabolic Regulator in Genetic Disorders Cancer and Microbial Pathogenesis

PTS serves as a critical enzyme in the tyrosine biosynthesis pathway, with significant implications across multiple pathological conditions. In metabolic disorders, its dysregulation contributes to hereditary tyrosinemia type I through toxic metabolite accumulation, causing severe liver dysfunction and neurological complications. The enzyme's role in phenylalanine metabolism links it to phenylketonuria (PKU), where impaired activity leads to neurocognitive deficits. Oncological research reveals its overexpression in certain malignancies, promoting tumor proliferation through enhanced aromatic amino acid production supporting protein synthesis. In neurodegenerative diseases, abnormal activity correlates with dopamine metabolism disturbances observed in Parkinson's pathology. Microbial pathogenesis studies highlight its essentiality in bacterial folate synthesis, making it a potential target for antimicrobial development against drug-resistant strains. Recent investigations also demonstrate involvement in inflammatory bowel diseases through gut microbiome modulation of aromatic amino acid availability. The multifaceted roles in fundamental metabolic pathways position this target as particularly valuable for therapeutic intervention in conditions where amino acid imbalance, proliferative signaling, or microbial pathogenesis drive disease progression. Small molecule inhibitors and genetic modulation approaches show particular promise in preclinical models addressing these diverse mechanisms.

Alternative Names

Complement PTS; 6-Pyruvoyltetrahydropterin Synthase; PTP Synthase; PTPS; 6-Pyruvoyl Tetrahydrobiopterin Synthase; EC 4.2.3.12

Background

The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.

Anti-PTS rAb Products

We enable faster breakthroughs in PTS research by providing rigorously validated recombinant antibodies that deliver both outstanding performance and cost-efficiency. Our scientists offer personalized experimental support and troubleshooting guidance to help you achieve reliable results quickly.

Table 1. Featured anti-PTS recombinant antibody products at Creative Biolabs.

Creative Quality Control

We accelerate biopharmaceutical innovation from discovery to market through customer-focused solutions backed by rigorous quality systems. Our commitment to exceeding industry standards helps researchers streamline development timelines while maintaining uncompromising product reliability throughout the commercialization process.

Customer Reviews

Excellent

Cy**s
Mouse Anti-PTS Recombinant Antibody (clone 39G11) (CAT#: MOB-1933z)

The Mouse Anti-PTS Antibody worked reliably in ELISA with recombinant protein samples, showing good sensitivity at 1:2000 dilution. We also tested it in WB using HEK293 lysates, where it detected a clean band at the expected size. While it performed consistently across batches, some background appeared in tissue homogenates unless blocking time was extended. A solid choice for basic detection assays.

16/Oct/2024

Excellent

J**is
Recombinant Mouse anti-Human PTS Monoclonal antibody (BU3C3) (CAT#: MOB-1725CT)

The Recombinant Mouse anti-Human PTS antibody performed well in Western blotting with HeLa and HepG2 cell lysates, showing a clean ~50kDa band at 1:1000 dilution. While the signal was strong, we noticed slight non-specific binding in mouse liver homogenates that required extended blocking. It worked consistently across multiple lots, though optimal dilution varied slightly between cell types. The antibody hasn't been tested in IP applications yet, but performs reliably for basic WB needs. Some optimization may be needed for tissue samples.

03/Sep/2024

Excellent

Lo**i
Rabbit Anti-PTS (pS19) Recombinant Antibody (clone R05-7G8) (CAT#: VS3-WK2041)

The Rabbit Anti-PTS antibody worked well in WB with stimulated HEK293T lysates, specifically detecting the phosphorylated form at ~50kDa. Minimal background was observed in brain tissue homogenates after optimizing blocking conditions. While it showed good specificity for the phosphorylated epitope, the signal intensity varied slightly between stimulation timepoints. Reliable for basic phospho-protein detection when proper controls are included.

25/Nov/2023

rAb Production

With over a decade of specialized experience in antibody engineering, we've refined our processes to deliver premium recombinant antibodies that combine exceptional performance with rapid turnaround times. Our customer-focused approach ensures each product undergoes rigorous quality validation while maintaining cost-efficiency for research budgets.

Featured Anti-PTS Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs provides researchers with a diverse portfolio of engineered antibody solutions, developed through advanced recombinant technologies. Our expertise spans multiple antibody formats and customization approaches, supported by tailored development services to address unique experimental requirements with reliability.

Fig.4 Full Length Anti-PTS Recombinant Antibody Production and Modalities.

For further details about PTS or technical guidance on your experiments, please contact our scientific team by phone or email. We provide personalized support to help troubleshoot challenges, optimize protocols, and interpret results—ensuring your research progresses efficiently while maintaining the highest experimental standards.